American Airlines Flight 550 traveling from Phoenix to Boston made an emergency landing in Syracuse, New York, on Monday after the flight's captain had a medical emergency.
CNN reported that the pilot died during the flight.
The Airbus A320 jet with 152 passengers and crew on board landed safely with the copilot at the controls.
"American Airlines Flight 550, an Airbus A320, diverted to Syracuse Hancock International Airport (SYR) early this morning due to pilot illness," American Airlines said in an emailed statement.
"Unfortunately, our pilot passed away. We are incredibly saddened by this event, and we are focused on caring for our pilot's family and colleagues."
AA Flight 550 took off from Phoenix Sky Harbor Airport on Sunday at 11:55 p.m. local time and landed in Syracuse at 7:13 a.m. Monday.
According to the Airline, a replacement crew was dispatched to get the passengers to Boston.